Coco gets the start over red hot Jacoby, Drew is still in the lead-off spot.
| J.D. Drew, RF | |
| Dustin Pedroia, 2B | |
| David Ortiz, DH | |
| Kevin Youkilis, 1B | |
| Mike Lowell, 3B | |
| Jason Bay, LF | |
| Jed Lowrie, SS | |
| Jason Varitek, C | |
| Coco Crisp, CF
Jon Lester, SP |
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